Exploring the intricate mechanisms underlying Alzheimer’s disease for developing effective treatments.

AD-Alterome is a comprehensive database featuring AD-specific biomarker regulatory events, meticulously mined from scientific literature. Our platform is designed to enhance the investigation of Alzheimer's Disease (AD) pathology, offering a rich, accurate, and specific resource for researchers.

Key Features

Customized Biomarker Regulatory Event Templates

Our approach involves using specially designed templates to identify AD-specific biomarker regulatory events from literature. This ensures the extraction of high-quality, precise information relevant to AD pathology.

Comprehensive Database

The AD-Alterome database is a specialized repository for AD, providing a centralized location for researchers to access and explore relevant data. This database supports efficient data retrieval, evidence display, and results visualization.

Functional Modules

  • Single/Multi-Gene Investigation:

    Researchers can quickly search for biomarker regulatory event descriptions associated with genes of interest. Each event is backed by literature support, facilitating targeted research.

  • Phenotype/Gene Recommendation:

    Utilizing a specific recommendation algorithm, this module accelerates the prioritization of AD-specific gene-phenotype associations. It also provides the necessary evidence to support these associations, streamlining the research process.

  • Gene-Set Enrichment Analysis:

    Based on the hypergeometric test algorithm, this feature allows for the investigation of AD-specific gene function enrichment. It reveals potential functional associations, aiding in the understanding of AD pathology.

User Experience

  • Interactive Visualizations:

    All data pages include interactive visualizations, making it easier for researchers to interpret complex data.

  • Concise Literature Evidence:

    Each piece of data is supported by clear, concise references to the original literature, ensuring the reliability and validity of the information provided.

AD-Alterome serves as a valuable data resource and effective tool for gene- and phenotype-centered exploration of AD pathology, offering researchers the means to uncover deeper insights into Alzheimer's Disease mechanisms.


[1] Xinzhi Yao, Zhihan He, Yuxing Wang, Anastasios Nentidis, Ziming Tang, Georgios Katsimpras, Xuan Xu, Xiangyu Meng, Jin-Dong Kim, Jinchen Li, Leiyu Feng, Yuan Quan, George Paliouras, Jingbo Xia. "AD-Alterome: A Resource of Literature-mined Pathology Investigation for Alzheimer’s Disease."

In Preparation

Developing Team


Affiliation: College of Informatics, Huazhong Agricultural UniversityChina, Wuhan, Hubei, China

Main Developer: Xinzhi Yao     Email:

Lab PI: Jingbo Xia