| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Positive regulation | 25689586 | Thus, loss of function single-nucleotide polymorphisms (SNPs) in TREM2 that increase AD risk are thought to decrease Abeta phagocytosis and promote a pro-inflammatory response. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Positive regulation | 26733934 | Inflammation plays a role in AD and other neurodegenerative disorders, and genetic variants related to the TREM2 gene increase the risk of AD and other dementias. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Positive regulation | 33065553 | Recently, deficiency of TREM2 downregulated plaque-associated microglia and activated inflammatory response in AD mouse, suggesting that TREM2 is necessary for microglia to response to amyloid plaques(Abeta) and anti-inflammation. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Positive regulation | 30572908 | On the other hand, a recent in vitro study using a microglia/neuron co-culture model, reported that depletion of TREM2 exacerbated tau phosphorylation via an increase in the microglial inflammatory response. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Positive regulation | 33198789 | TREM2 deficiency has been reported to potentiate bacterial lipopolysaccharide (LPS)-induced inflammation in mouse bone marrow-derived macrophages, but not human microglia-like cells. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Positive regulation | 31068799 | In carriers of TREM2 mutations, the inflammation response is much enhanced, and pro-inflammatory cytokines are increased. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Positive regulation | 23533697 | Because TREM2 functions to modulate the inflammatory immune responses in microglia, mutations in this gene, in turn, could contribute to disease pathogenesis by preventing the clearance of beta-amyloid deposits and/or by enhancing inflammation. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Positive regulation | 25499537 | Thus, the association of the TREM2 missense mutation with more severe neuropathology and increased inflammation may mark a signaling pathway/network central to the etiology of AD. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Positive regulation | 28768545 | TREM2 deficiency also resulted in increased levels of IFNgamma, TNFalpha and iNOS following colonic mucosal injury and TREM2 knockdown or antibody-mediated inhibition increased expression of many inflammation-related cytokines following corneal infection. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Negative Regulation | 32630597 | In the BV-2 cell, knockdown of TREM2 expression increases M1 inflammatory responses and inhibits phenotype switching to M2, while overexpression of TREM2 promotes phenotype change to M2 and alleviated inflammation of M1. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Negative Regulation | 28713239 | The mutations of TREM2 and CD33 will lead to reduced Abeta clearance and an increased inflammatory response. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Negative Regulation | 31216982 | In recent studies of rare TREM2 variants associated with LOAD with large effect sizes, attenuation of the inflammatory response and immune function in the nervous system, particularly in microglia, was reported to contribute to AD onset. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Negative Regulation | 26071899 | At this time it is important to remember that a conflicting reports have been published showing a beneficial effect of global deletion of Trem2, with reduced inflammation and ameliorated amyloid and tau pathologies. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Negative Regulation | 26870779 | Loss of function mutations of TREM2 or TYROBP are linked to highly inflammatory Nasu-Hakola disease in human, whereas disruption of TREM2 in amyloid precursor protein (APP)-overexpressing mice, a model of AD, results in reduced inflammation and Abeta accumulation in mouse brain. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Negative Regulation | 24355566 | Here we propose that the mechanism(s) by which TREM2 variants cause Alzheimer's disease are via down regulation of the Abeta phagocytic ability of microglia and by dysregulation of the pro-inflammatory response of these cells. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Negative Regulation | 27939925 | In a different mouse model of AD (APP/PS1), knock-out of Trem2, resulted in reduction of macrophages infiltrating from the periphery, along with less brain inflammation and reduced amyloid and tau pathology. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | copy number variation | Negative Regulation | 31543810 | showed that TREM2 deficiency in APP/PS1 mice reduces the pro-inflammatory response. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Negative Regulation | 29859094 | Therefore, we wanted to assess whether the Trem2 R47H variant would also impair the inflammatory response to AD pathology. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Association | 28768545 | A variant within intron 2 of TREM2, which is prevalent in African American individuals, was found to be significantly associated with levels of C-reactive protein (CRP), a systemic marker of inflammation, whose expression is primarily driven by IL6 and IL1beta. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Association | 28768545 | Likewise, a TREM2 variant was associated with markers of systemic inflammation specifically in women not men, and was hormone-independent. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Association | 23533697 | Recently, a novel variant in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has been identified that has refocused the spotlight back onto inflammation as a major contributing factor in AD. |
| 54209 | TREM2 | GO:0006954 | inflammatory response | point mutations | Association | 29707568 | Mutation or aberrations that give rise to single-nucleotide polymorphism (rs75932628) within TREM2 are associated with disruption in the expression of TREM2 receptor that triggers inflammatory response, oxidative radicals, and neurotoxin production and eventually production of Abeta protein. |