| 2 | A2M | HP:0002185 | Neurofibrillary tangles | point mutations | Association | 24011543 | The SNP rs669 has been associated with argyrophilic grain disease, a disease that may have neurofibrillary lesions that are typical of AD, but meta-analyses of rs3832852 and rs669 association studies show no significant allele frequency differences between AD cases and controls, even after stratification by APOE epsilon4. |