105375056 | LOC105375056 | HP:0002185 | Neurofibrillary tangles | point mutations | Positive regulation | 25545807 | A variant upstream of TREM2, rs7759295C, is independently associated with an increased Tau tangle density (p=4.9x10-4), an increased burden of neurofibrillary tangles (p=9.1x10-3), and an increased rate of cognitive decline (p=2.3x10-3). |
105375056 | LOC105375056 | HP:0002185 | Neurofibrillary tangles | point mutations | Positive regulation | 25545807 | A variant upstream of TREM2, rs7759295(C) , is independently associated with an increased tau tangle density (p = 4.9 x 10(-4) ), an increased burden of neurofibrillary tangles (p = 9.1 x 10(-3) ), and an increased rate of cognitive decline (p = 2.3 x 10(-3) ). |