AD-PNRLE

AD-Pathological Network with Rich Literature Evidence

Drug Mechanism







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Brief description

The queried drug is "DB00674-Galantamine", 2 target is found in PNRLE, including "ACHE an BCHE".
The results of the AD-PNRLE are as follows:

1. A total of 6 pathways are retrieved, with an average length of 5.9 for each pathway.

2. A total of 1 literature are retrieved related to the query gene(s), with an average of 0.2 texts for each pathway.

3. There are 1 mutations directly associated with the query gene(s). Among them, mutation "BCHE:variant" is related to the most pathway, with 1.

4. There are 4 biological process terms, 2 phenotypic symptom terms, and 0 diseases associated with the query gene(s). The most frequently reported biological process term is "Apoptosis of neurons" (1 times), the phenotypic symptom term is "Amyloidosis" (1 times), and the disease is "None" (0 times) .

5. There are 0 genes linked to the query gene(s) by mutations and other biomarker.

Entrez Symbol Mutation Term ID Term Name PathwayLength
590 BCHE 590:Var-Mutations GO:0070997 neuron death 6.0
590 BCHE 590:Var-Mutations GO:0051402 Apoptosis of neurons 6.0
590 BCHE 590:Var-Mutations HP:0100256 Senile Plaques 6.0
590 BCHE 590:Var-Mutations GO:0070997 neuron death 6.0
590 BCHE 590:Var-Mutations HP:0100256 Senile Plaques 6.0
590 BCHE 590:Var-Mutations HP:0100256 Senile Plaques 6.0