AD-Pathological Network with Rich Literature Evidence

Symptom Query


Brief description

The query term(s) is/are Neurodegenerative Disorder. The results of the AD-PNRLE are as follows:

1. A total of 8 literature are retrieved related to the query gene(s), with an average of 8.

2. There are 9 mutations directly associated with the query gene(s). Among them, mutation "MEIS1:rs2300478" is related to the most GO terms, with 0.

3. There are 0 biological process terms, 0 phenotypic symptom terms, and 1 diseases associated with the query gene(s). The most frequently reported biological process term is "None" (0 times), the phenotypic symptom term is "None" (0 times), and the disease is "Neurodegenerative disorder" (1 times).

4. There are 8 genes linked to the query gene(s) by mutations and descriptors.

Entrez Symbol Mutation Relation Term ID Term Name Evidence Table
5663 PSEN1 rs63750231 Association MESH:D019636 Neurodegenerative disorder Jump
1312 COMT rs4680 Association MESH:D019636 Neurodegenerative disorder Jump
3077 HFE rs1800562 Negative regulation MESH:D019636 Neurodegenerative disorder Jump
54209 TREM2 rs75932628 Positive regulation MESH:D019636 Neurodegenerative disorder Jump
4211 MEIS1 rs2300478 Association MESH:D019636 Neurodegenerative disorder Jump
351 APP rs145081708 Association MESH:D019636 Neurodegenerative disorder Jump
4854 NOTCH3 rs55882518 Association MESH:D019636 Neurodegenerative disorder Jump
120892 LRRK2 rs34637584 Positive regulation MESH:D019636 Neurodegenerative disorder Jump
51606 ATP6V1H rs1481950 Association MESH:D019636 Neurodegenerative disorder Jump